dc.contributor.author | Evingür, Gülşen Akın | en_US |
dc.contributor.author | Karslı, Kadir | en_US |
dc.contributor.author | Pekcan, Mehmet Önder | en_US |
dc.date.accessioned | 2015-01-15T23:00:33Z | |
dc.date.available | 2015-01-15T23:00:33Z | |
dc.date.issued | 2006-12-01 | |
dc.identifier.citation | Evingür, G. A., Karslı, K. & Pekcan, M. Ö. (2006). Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique. International Journal of Pharmaceutics, 326(1-2), 7-12. doi:10.1016/j.ijpharm.2006.06.043 | en_US |
dc.identifier.issn | 0378-5173 | |
dc.identifier.issn | 1873-3476 | |
dc.identifier.uri | https://hdl.handle.net/11729/201 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.ijpharm.2006.06.043 | |
dc.description.abstract | steady state fluorescence technique was used to study small molecule diffusion into polyacrylamide (PAAm) gels at various temperatures. Pyranine (P-y), dissolved in water was introduced as a probe and fluorescence emission (I-p) from Py was monitored during diffusion. Scattered light intensities, I-sc from PAAm gel was also monitored to observe structural variations during diffusion process. Increase in I-P intensity was attributed to P-Y diffusion into PAAm get. On the other hand decrease in I-sc intensity was interpreted as the variation of the spatial heterogeneities in the system. Li-Tanaka and Fickian models were used to quantify the swelling and diffusion experiments and diffusion coefficients were produced in both cases. Related activation energies were also calculated from the corresponding physical processes. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.isversionof | 10.1016/j.ijpharm.2006.06.043 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Diffusion | en_US |
dc.subject | Hydrogel | en_US |
dc.subject | Fluorescence | en_US |
dc.subject | Temperatures | en_US |
dc.subject | Photon transmission technique | en_US |
dc.subject | Polyacrylamide gels | en_US |
dc.subject | Phase-transition | en_US |
dc.subject | Real-time | en_US |
dc.subject | Kinetics | en_US |
dc.subject | Collapse | en_US |
dc.subject | Release | en_US |
dc.subject | Biophysics | en_US |
dc.subject | Chemistry, Pharmaceutical | en_US |
dc.subject | Gels | en_US |
dc.subject | Models | en_US |
dc.subject | Statistical | en_US |
dc.subject | Particle size | en_US |
dc.subject | Solubility | en_US |
dc.subject | Spectrometry, Fluorescence | en_US |
dc.subject | Water | en_US |
dc.subject | Diffusion coefficient | en_US |
dc.subject | Light scattering | en_US |
dc.subject | Priority journal | en_US |
dc.subject | Steady state | en_US |
dc.title | Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique | en_US |
dc.type | article | en_US |
dc.description.version | Publisher's Version | en_US |
dc.relation.journal | International Journal of Pharmaceutics | en_US |
dc.contributor.department | Işık Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü | en_US |
dc.contributor.department | Işık University, Faculty of Arts and Sciences, Department of Physics | en_US |
dc.contributor.authorID | 0000-0002-0082-8209 | |
dc.identifier.volume | 326 | |
dc.identifier.issue | 1-2 | |
dc.identifier.startpage | 7 | |
dc.identifier.endpage | 12 | |
dc.peerreviewed | Yes | en_US |
dc.publicationstatus | Published | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Pekcan, Mehmet Önder | en_US |
dc.relation.index | WOS | en_US |
dc.relation.index | Scopus | en_US |
dc.relation.index | PubMed | en_US |
dc.relation.index | Science Citation Index Expanded (SCI-EXPANDED) | en_US |
dc.description.quality | Q1 | |
dc.description.wosid | WOS:000242257500002 | |
dc.description.pubmedid | PMID:16889915 | |