Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy
Göster/ Aç
Tarih
2023Yazar
Orhun, GünseliEsen, Figen
Yılmaz, Vuslat
Ulusoy, Canan
Şanlı, Elif
Yıldırım, Elif
Gürvit, İbrahim Hakan
Ergin Özcan, Perihan
Sencer, Serra
Bebek, Nerses
Tüzün, Erdem
Üst veri
Tüm öğe kaydını gösterKünye
Orhun, G., Esen, F., Yılmaz, V., Ulusoy, C., Şanlı, E., Yıldırım, E., Gürvit, İ. H., Ergin Özcan, P., Sencer, S., Bebek, N. & Tüzün, E. (2023). Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy. International Journal of Neuroscience, 133(3), 327-333. doi: 10.1080/00207454.2021.1916489Özet
Purpose: Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis that may lead to cognitive decline. Our aim was to investigate whether the neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could be utilized as prognostic biomarkers in SAE. Materials and methods: In this prospective observational study, baseline serum levels of sTREM2 and cerebrospinal fluid (CSF) levels of sTREM2 and NFL were measured by ELISA in 11 SAE patients and controls. Patients underwent daily neurological examination. Brain magnetic resonance imaging (MRI) and standard electroencephalography (EEG) were performed. Cognitive dysfunction was longitudinally assessed after discharge in 4 SAE patients using the Mini-Mental State Examination (MMSE) and Addenbrooke’s Cognitive Examination-Revised (ACE-R) tests. Results: SAE patients showed higher CSF sTREM2 and NFL levels than controls. sTREM2 and NFL levels were not correlated with the severity measures of sepsis. Three months after discharge, 2 SAE patients displayed ACE-R scores congruent with mild cognitive impairment (MCI), persisting in one patient 12 months after discharge. SAE patients with MCI showed higher CSF NFL levels, bacteremia, and abnormal brain MRI. Patients with increased serum/CSF sTREM2 levels showed trends towards displaying poorer attention/orientation and visuo-spatial skills. Conclusions: sTREM2 and NFL levels may serve as a prognostic biomarker for cognitive decline in SAE. These results lend further support for the involvement of glial activation and neuroaxonal degeneration in the physiopathology of SAE.
Cilt
133Sayı
3Koleksiyonlar
Aşağıdaki lisans dosyası bu öğe ile ilişkilidir: