Effects of laurocerasus officinalis roem (Cherry Laurel) on cognitive function and neurobiochemical pathways in a streptozotocin-induced nontransgenic Alzheimer's disease model

Basit Öğe Kaydı
dc.authorid0000-0001-9213-8354
dc.authorid0000-0001-6571-415X
dc.authorid0000-0002-5925-2128
dc.authorid0000-0001-8219-4205
dc.authorid0000-0002-1347-8498
dc.contributor.authorÖzsoy, Fulyaen_US
dc.contributor.authorYanar, Karolinen_US
dc.contributor.authorSayılı, Uğurcanen_US
dc.contributor.authorAtukeren, Pınaren_US
dc.contributor.authorUzun, Hafizeen_US
dc.date.accessioned2026-03-30T12:54:17Z
dc.date.available2026-03-30T12:54:17Z
dc.date.issued2026-03-08
dc.departmentIşık Üniversitesi, Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Programıen_US
dc.departmentIşık University, Vocational School, Occupational Health and Safety Programen_US
dc.descriptionThis study was supported by The Research Fund of Istanbul University (Project No. BAP: 33036).en_US
dc.description.abstractBackground: This study investigated the effects of Laurocerasus officinalis Roem (cherry laurel; CL), a traditionally consumed fruit, on cognitive performance and selected neurobiochemical and metabolic pathways in a nontransgenic streptozotocin (STZ)-induced Alzheimer’s disease (i.c.v. STZ) model and an STZ-induced type 2 diabetes mellitus (T2DM; i.p. STZ) model. Method: Fifty-seven adult male Sprague–Dawley rats were allocated to control, T2DM, and Alzheimer (ALZ) model groups, with subgroup interventions including CL supplementation and, in the T2DM model, metformin as a comparator. Spatial learning and memory were assessed using the Morris Water Maze. Serum and brain tissue levels of GSK3-β, glutathione (GSH), interleukin-1 (IL-1), GLUT4, GLP-1, β-amyloid (Aβ), and acetylcholinesterase (AChE) were quantified. Results: Serum GSK3-β levels did not differ significantly between groups, whereas brain tissue GSK3-β showed significant between-group differences. CL increased GSH levels in both models, with significant elevations in serum and brain tissue GSH in the ALZ model following CL administration; in the T2DM model, GSH increased after both CL and metformin. In the ALZ model, CL was associated with decreased serum Aβ and AChE levels and improved Morris Water Maze performance, reflected by reduced escape latencies. Conclusions: CL supplementation was associated with antioxidant enhancement and modulation of amyloid- and cholinergic-related measures, alongside improved spatial learning performance in the STZ-induced nontransgenic ALZ model. In addition, CL reduced blood glucose in the T2DM model. Given the likely contribution of fruit phytochemicals (including total phenolics), further studies are warranted to better define the bioactive composition and mechanisms underlying these effects.en_US
dc.description.sponsorshipIstanbul Universityen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationÖzsoy, F., Yanar, K., Sayılı, U., Atukeren, P. & Uzun, H. (2026). Effects of laurocerasus officinalis roem (Cherry Laurel) on cognitive function and neurobiochemical pathways in a streptozotocin-induced nontransgenic Alzheimer's disease model. Nutrients, 18(5), 1-19. doi:https://doi.org/10.3390/nu18050867en_US
dc.identifier.doi10.3390/nu18050867
dc.identifier.endpage19
dc.identifier.issn2072-6643
dc.identifier.issue5
dc.identifier.pmid41830037
dc.identifier.scopus2-s2.0-105032783120
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/7195
dc.identifier.urihttps://doi.org/10.3390/nu18050867
dc.identifier.volume18
dc.identifier.wosWOS:001713785400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÖzsoy, Fulyaen_US
dc.institutionauthorid0000-0001-9213-8354
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofNutrientsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectCherry Laurelen_US
dc.subjectGSK3-βen_US
dc.subjectMoris water mazeen_US
dc.subjectType 2 diabetesen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectAnimalsen_US
dc.subjectBrainen_US
dc.subjectCognitionen_US
dc.subjectDiabetes mellitusen_US
dc.subjectExperimentalen_US
dc.subjectType 2en_US
dc.subjectDisease modelsen_US
dc.subjectFruiten_US
dc.subjectGlutathioneen_US
dc.subjectGlycogen synthase kinase 3 betaen_US
dc.subjectMaze learningen_US
dc.subjectMetforminen_US
dc.subjectPlant extractsen_US
dc.subjectRatsen_US
dc.subjectSprague-dawleyen_US
dc.subjectStreptozocinen_US
dc.subjectBlooden_US
dc.subjectChemistryen_US
dc.subjectDrug effecten_US
dc.subjectDrug therapyen_US
dc.subjectExperimental diabetes mellitusen_US
dc.subjectMaze testen_US
dc.subjectMetabolismen_US
dc.subjectNon insulin dependent diabetes mellitusen_US
dc.subjectPsychologyen_US
dc.subjectRaten_US
dc.subjectSprague dawley raten_US
dc.titleEffects of laurocerasus officinalis roem (Cherry Laurel) on cognitive function and neurobiochemical pathways in a streptozotocin-induced nontransgenic Alzheimer's disease modelen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Effects_of_Laurocerasus_Officinalis_Roem_Cherry_Laurel_on_Cognitive_Function_and_Neurobiochemical_Pathways_in_a_Streptozotocin_Induced_Nontransgenic_Alzheimers_Disease_Model.pdf
Boyut:
2.82 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu