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Yayın Computational model of the ventricular action potential in adult spontaneously hypertensive rats(2003-09-01) Padmala, Srikanth; Demir, Sıddıka SemahatIntroduction: Cardiac hypertrophy has substantial clinical significance because many hypertrophic cells have markedly prolonged repolarization behavior, which may lead to increased risk for cardiac arrhythmias. Spontaneously hypertensive rat (SHR) is one model of hypertension that is studied extensively and is considered to be the best laboratory model of human hypertension. We extended our previously published model of the rat ventricular myocyte to simulate the effects of hypertrophy in SHR. Methods and Results: In SHR it has been shown that the membrane capacitance is increased, the density of transient outward K+ current is decreased, the sarcoplasmic reticulum Ca 2+ ATPase activity is reduced, and the cell volumes are increased compared to those of the normal rat. We introduced these changes into our previous model of the rat ventricular myocyte and simulated the ventricular action potential of SHR. Our results demonstrated increased action potential duration (APD) and increased peak systolic value of the intracellular calcium transient in SHR. Simulations with reduced extracellular K+ concentration ([K+]o) have shown that there is increased APD shortening in SHR compared to that of the normal rat. Conclusions: Our computational model qualitatively simulated the electrophysiologic changes observed in SHR and provided the plausible mechanistic linkage between the prolonged APD and increased inotropy. Our model results also demonstrated the electrophysiologic changes observed with reduced [K+]o in SHR, a finding that is clinically significant in hypertensive patients with left ventricular hypertrophy undergoing diuretic treatment.Yayın Peer-mentoring among female biomedical engineering students can be extended to other engineering disciplines(2004-06) Demir, Sıddıka SemahatMentoring is significant personal and professional assistance given by a more experienced person to a less experienced person during a time of transition. Transitions from high school to university, from university to graduate school are difficult. Organizing and administering mentoring programs in schools or in professional societies provide good recruitment and retention of female students in engineering. Biomedical engineering (BME) is the engineering discipline that has the highest percentage of female degree recipients and tenure/tenure-track teaching faculty as seen presented in "ASEE Profiles of Engineering and Engineering Technology Colleges, 2001 Education. Engineering Education by the Numbers". Thus there is a great potential for female role models, mentors and mentees in BME. Recently, I have a developed a mentoring program for women at the Joint Graduate Biomedical Engineering Program of University of Memphis (UM) and University of Tennessee Health Science Center (UT). Currently our program focuses on peer-mentoring and community building. We follow the book "Giving Much/Gaining More: Mentoring for Success" by Dr. Wadsworth for our meetings and activities to provide a support and discussion group, and environment to women in their transition time of the BME graduate studies. Our future goal is to expand our mentoring program to female students in our engineering school since we believe that the women in BME are excellent role models, mentors and mentees to women in other engineering disciplines.
