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Yayın Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder(Elsevier Science BV, 2014-06-20) Erten, Evrim; Funda Uney, Aslı; Saatçioğlu, İbrahim Ömer; Özdemir, Armağan; Fıstıkçı, Nurhan; Çakmak, DuranBackground: We explored how childhood trauma (CHT) affects the clinical expression of disorder and quality of life in patients with bipolar I (BP I) disorder.Methods: Euthymic patients (n=116) who subsequently received a diagnosis of BP-I disorder were consecutively included and were interviewed using the following sociodemographic and clinical data forms; Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Childhood Abuse and Neglect Questionnaire (CANQ) and the 36 item Medical Outcome Study Short Form Health Survey (SF 36) The quality of life of BP-I patients with and without a history of CHT were examined.Results: The percentage of trauma was 61.2%. Patients who had CHT had higher frequencies of depressive episodes (t = -2.38, p=0.019), total episodes (t = -2.25, p=0.026), attempted suicide more often (chi(2)=18.12, p=0.003) and had lower scores on the pain subscale of Lhe SF 36 (z=-2.817, p=0.005). In patients with mixed or rapid-cycling episodes, SF-36 subscale scores except general health and pain were Found to be lower.Limitations: Our sample may fail to reflect the general BD population; the patients were included consecutively and consisted of a majority of female patients.Conclusions: CHT plays an important role in the clinical expression of BP-I disorder and having mixed/rapid-cycling episodes negatively affects both physical and mental components, as measured by the SF-36. While both males and females reported experiencing sexual abuse, female BP-I patients complained about pain more often. It is suggested that treatment of BP-1 patients with a history of CHT should differ from that provided for patients with no CHT history.Yayın Attentional bias and training in social anxiety disorder(Turkish Neuropsychiatric Society, 2015-03) Fıstıkçı, Nurhan; Saatçioğlu, İbrahim Ömer; Keyvan, Ali; Topçuoǧlu, VolkanCognitive behavioral therapy (CBT) is one of the most effective treatment modalities for social anxiety disorder (SAD), showing a high level of clinical evidence supporting its effectiveness. On the other hand, lack of the desired benefit from this treatment in some patients causes continuation of the search for new techniques. Recent research studies have focused on attentional bias and attention training in SAD. Attention processes in SAD have been a major target of interest and investigation since the introduction of the first cognitive models explaining SAD. In the first model, it was highlighted that attention was self-focused. The relationship between threatening stimuli and attention was considered in the subsequent models. Attentional bias towards threat may take place in several ways, such as facilitated processing of threat, difficulty in disengaging attention from the threat and avoidance of attention from the threat. After these descriptions regarding the phenomenology of the disorder, treatments to modify attention, processes were developed. In spite of conflicting results, investigations on attentional training are promising. Attention processes, attentional bias and attentional training in SAD are discussed in this review.Yayın Olanzapin kullanımına bağlı çekilme diskinezisi ve süpersensitivite psikozu(Turkish Neuropsychiatric Society, 2016-06) Karaş, Hakan; Güdük, Mehmet; Saatçioğlu, İbrahim ÖmerTardive dyskinesia (TD) usually appears after years of antipsychotic drug use and appears to be related to the total lifetime medication dose. In withdrawal-emergent dyskinesia (WE-D), which is considered to be a subtype of TD, dyskinetic symptoms often appear shortly after a rapid reduction in antipsychotic drug dose or sudden discontinuation of the drug. Supersensitivity psychosis, which is frequently observed along with TD and is considered to have a similar etiology as TD, is a psychotic relapse phenomenon that occurs after the withdrawal of an antipsychotic drug or a rapid reduction in the drug dosage. In general, atypical antipsychotics tend to be associated with less propensity to cause TD when compared with typical antipsychotics. Furthermore, olanzapine and clozapine may have a therapeutic potential in improving or totally curing TD. In this study, a case of WE-D because of discontinuing olanzapine use and supersensitivity psychosis is discussed.
