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Yayın Uyarlanır yerel bağlı katman kullanan dikkat tabanlı derin ağ ile sesli komut tanıma(Institute of Electrical and Electronics Engineers Inc., 2020-10-05) Turkan, Yasemin; Tek, Faik BoraySesli komut tanıma insan-makine ara yüzüyle ilişkili aktif bir araştırma konusudur. Dikkat tabanlı derin ağlar ile bu tür problemler başarılı bir şekilde çözülebilmektedir. Bu çalışmada, var olan bir dikkat tabanlı derin ağ yöntemi, uyarlanır yerel bağlı (odaklanan) katman kullanılarak daha da geliştirilmiştir. Orijinal yönteminde sınandığı Google ve Kaggle sesli komut veri setlerinde karşılaştırmalı olarak yapılan deneylerde önerdiğimiz uyarlanır yerel bağlı katman kullanan dikkat tabanlı ağın tanıma doğruluğunu %2.6 oranında iyileştirdiği gözlemledik.Yayın Automated diagnosis of Alzheimer’s Disease using OCT and OCTA: a systematic review(Institute of Electrical and Electronics Engineers Inc., 2024-08-06) Turkan, Yasemin; Tek, Faik Boray; Arpacı, Fatih; Arslan, Ozan; Toslak, Devrim; Bulut, Mehmet; Yaman, AylinRetinal optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) have emerged as promising, non-invasive, and cost-effective modalities for the early diagnosis of Alzheimer's disease (AD). However, a comprehensive review of automated deep learning techniques for diagnosing AD or mild cognitive impairment (MCI) using OCT/OCTA data is lacking. We addressed this gap by conducting a systematic review using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. We systematically searched databases, including Scopus, PubMed, and Web of Science, and identified 16 important studies from an initial set of 4006 references. We then analyzed these studies through a structured framework, focusing on the key aspects of deep learning workflows for AD/MCI diagnosis using OCT-OCTA. This included dataset curation, model training, and validation methodologies. Our findings indicate a shift towards employing end-to-end deep learning models to directly analyze OCT/OCTA images in diagnosing AD/MCI, moving away from traditional machine learning approaches. However, we identified inconsistencies in the data collection methods across studies, leading to varied outcomes. We emphasize the need for longitudinal studies on early AD and MCI diagnosis, along with further research on interpretability tools to enhance model accuracy and reliability for clinical translation.Yayın Retinal disease diagnosis in OCT scans using a foundational model(Springer Science and Business Media Deutschland GmbH, 2025) Nazlı, Muhammet Serdar; Turkan, Yasemin; Tek, Faik Boray; Toslak, Devrim; Bulut, Mehmet; Arpacı, Fatih; Öcal, Mevlüt CelalThis study examines the feasibility and performance of using single OCT slices from the OCTA-500 dataset to classify DR (Diabetic Retinopathy) and AMD (Age-Related Macular Degeneration) with a pre-trained transformer-based model (RETFound). The experiments revealed the effective adaptation capability of the pretrained model to the retinal disease classification problem. We further explored the impact of using different slices from the OCT volume, assessing the sensitivity of the results to the choice of a single slice (e.g., “middle slice”) and whether analyzing both horizontal and vertical cross-sectional slices could improve outcomes. However, deep neural networks are complex systems that do not indicate directly whether they have learned and generalized the disease appearance as human experts do. The original dataset lacked disease localization annotations. Therefore, we collected new disease classification and localization annotations from independent experts for a subset of OCTA-500 images. We compared RETFound’s explainability-based localization outputs with these newly collected annotations and found that the region attributions aligned well with the expert annotations. Additionally, we assessed the agreement and variability between experts and RETFound in classifying disease conditions. The Kappa values, ranging from 0.35 to 0.69, indicated moderate agreement among experts and between the experts and the model. The transformer-based RETFound model using single or multiple OCT slices, is an efficient approach to diagnosing AMD and DR.Yayın Early Alzheimer's disease detection from retinal OCT images: a UK Biobank study(Cornell Univ, 2025-11-07) Turkan, Yasemin; Tek, Faik Boray; Nazlı, M. Serdar; Eren, ÖyküAlterations in retinal layer thickness, measurable using Optical Coherence Tomography (OCT), have been associated with neurodegenerative diseases such as Alzheimer's disease (AD). While previous studies have mainly focused on segmented layer thickness measurements, this study explored the direct classification of OCT B-scan images for the early detection of AD. To our knowledge, this is the first application of deep learning to raw OCT B-scans for AD prediction in the literature. Unlike conventional medical image classification tasks, early detection is more challenging than diagnosis because imaging precedes clinical diagnosis by several years. We fine-tuned and evaluated multiple pretrained models, including ImageNet-based networks and the OCT-specific RETFound transformer, using subject-level cross-validation datasets matched for age, sex, and imaging instances from the UK Biobank cohort. To reduce overfitting in this small, high-dimensional dataset, both standard and OCT-specific augmentation techniques were applied, along with a year-weighted loss function that prioritized cases diagnosed within four years of imaging. ResNet-34 produced the most stable results, achieving an AUC of 0.62 in the 4-year cohort. Although below the threshold for clinical application, our explainability analyses confirmed localized structural differences in the central macular subfield between the AD and control groups. These findings provide a baseline for OCT-based AD prediction, highlight the challenges of detecting subtle retinal biomarkers years before AD diagnosis, and point to the need for larger datasets and multimodal approaches.
