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Yayın The cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRI(Springer, 2020-09) Arslan, Dilek Betül; Gürvit, İbrahim Hakan; Genç, Ozan; Kıçik, Ani; Eryürek, Kardelen; Cengiz, Sevim; Erdoğdu, Emel; Yıldırım, Zerrin; Tüfekçioğlu, Zeynep; Uluğ, Aziz Müfit; Bilgiç, Başar; Hanağası, Haşmet Ayhan; Tüzün, Erdem; Demiralp, Tamer; Öztürk Işık, EsinParkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.Yayın A point cloud filtering method based on anisotropic error model(John Wiley and Sons Inc, 2023-12) Özendi, Mustafa; Akça, Devrim; Topan, HüseyinMany modelling applications require 3D meshes that should be generated from filtered/cleaned point clouds. This paper proposes a methodology for filtering of terrestrial laser scanner (TLS)-derived point clouds, consisting of two main parts: an anisotropic point error model and the subsequent decimation steps for elimination of low-quality points. The point error model can compute the positional quality of any point in the form of error ellipsoids. It is formulated as a function of the angular/mechanical stability, sensor-to-object distance, laser beam's incidence angle and surface reflectivity, which are the most dominant error sources. In a block of several co-registered point clouds, some parts of the target object are sampled by multiple scans with different positional quality patterns. This situation results in redundant data. The proposed decimation steps removes this redundancy by selecting only the points with the highest positional quality. Finally, the Good, Bad, and the Better algorithm, based on the ray-tracing concept, was developed to remove the remaining redundancy due to the Moiré effects. The resulting point cloud consists of only the points with the highest positional quality while reducing the number of points by factor 10. This novel approach resulted in final surface meshes that are accurate, contain predefined level of random errors and require almost no manual intervention.Yayın Eye movement desensitization and reprocessing therapy in adolescents with panic disorder: a twelve-week follow-up study(SAGE Publications Ltd, 2023-06-16) İnci İzmir, Sevim Berrin; Korkmazlar, Ümran; Ercan, Eyüp SabriThe aim of this study is to investigate the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) treatment in adolescents with panic disorder (PD). This follow-up study consists of 30 adolescents with PD without agoraphobia, aged 14–17 (15.53 ±.97). They were evaluated with Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present, also the Panic and Agoraphobia Scale (PAS) and Beck Anxiety Inventory (BAI) were administered at baseline, at the end of the 4th and 12th weeks of treatment. EMDR therapy which is an eight-phase treatment approach composed of standardized protocols and procedures was applied for 12 weeks, one session per week. The baseline mean of the total PAS score decreased from 40.06 to 13.13 at fourth week and 1.2 at the end of 12th week of treatment. In addition, BAI score decreased significantly from 33.67 to 13.83 at 4 weeks and 5.31 at the end of 12th week of treatment. Overall, our results underscore the effectiveness of EMDR in adolescents with PD. Moreover, the current study suggests that EMDR may represent an effective intervention technique for PD in adolescents to protect against relapses and to overcome a fear of future attacks.Yayın Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning(Springer Science and Business Media Deutschland GmbH, 2022-12) Cengiz, Sevim; Arslan, Dilek Betül; Kıçik, Ani; Erdoğdu, Emel; Yıldırım, Muhammed; Hatay, Gökçe Hale; Tüfekçioğlu, Zeynep; Uluğ, Aziz Müfit; Bilgiç, Başar; Hanagasi, Haşmet; Demiralp, Tamer; Gürvit, Hakan; Öztürk Işıkk, EsinObjective: To investigate metabolic changes of mild cognitive impairment in Parkinson’s disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (1H-MRSI). Methods: Sixteen healthy controls (HC), 26 cognitively normal Parkinson’s disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional 1H-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results: PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion: 1H-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as ‘posterior cortical metabolic changes’ related with cognitive dysfunction.Yayın Turkish sign language adaptation of the Turkish Health Literacy Scale-32(NLM (Medline), 2022-09-15) Ataseven Bulun, Mehtap; Çepni, Selden; Ermez, YusufSign language speakers are at a disadvantage in terms of health literacy due to the lack of health education materials in sign languages. Deaf and hard of hearing (DHH) individuals are excluded from health literacy research due to the lack of measurement tools in their language of excellent f luency. This study aims to provide the literature with a tool that allows the measurement of health literacy among DHH individuals. The Turkish Health Literacy Scale (THLS)-32 was translated into Turkish Sign Language (TSL). After the THLS-32 was translated into TSL in video format, it was tested for validity and reliability. The translated version of the scale was administered to participants from a DHH association in Turkey who are f luent in TSL. Subsequently, a study was conducted with 207 DHH individuals. The study group was assessed in terms of their mean index scores and evaluated to have “limited health literacy” according to the THLS-32 classification. We conclude that the THLS-32 in TSL is suitable to measure health literacy in DHH individuals and to assess the impact of the health education system.Yayın Tribo-corrosion behavior of electroplating, nitrocarburizing, and QPQ processes on barrel finishing(Walter de Gruyter GmbH, 2023-11-27) Yücel, Aysu Hande; Yılmaz, Alpay; Bakkal, Mustafa; Kuzu, Ali TanerIn this study, the effects of nitrocarburizing, QPQ, and Cr coating on the surface properties of 32CrMoV12-10 gun barrels are discussed. Hardness measurements, pin-on-disc tests, and anodic polarization tests were performed to examine the hardness values, wear resistance, friction coefficient, and corrosion resistance. The hardness of the specimen treated with QPQ was found to be the highest. Comparing the hardness profiles, it was observed that the casing depth of the nitrocarburized sample was shallower than that of the QPQ-treated sample. The pin-on-disc test revealed that the nitrocarburized sample exhibited a high coefficient of friction, while the Cr-coated sample showed the lowest coefficient of friction. Analyzing the Tafel polarization curve, it was determined that the nitrocarburized and QPQ-treated specimens demonstrated similar levels of corrosion resistance. However, it can be noted that the QPQ-treated specimen had a slightly lower corrosion rate.Yayın Psychological distress and anxiety among housewives: the mediational role of perceived stress, loneliness, and housewife burnout(Springer, 2023-06) Durak, Mithat; Durak, Emre Şenol; Karaköse, SelinHousewives are experiencing chronic stress when dealing with multiple roles (cooking, shopping, tidying the house) in their daily life. Although earlier studies have documented a significant link between role overload and stress-psychological well-being in the workplace, few studies have been conducted among housewives despite their high anxiety and burnout reports. The diathesis-stress model and transactional model of stress indicate that there may be somecontributory factors related to mental health. Within these frameworks, this research aimed to examine housewives' psychological distress and anxiety by focusing on three contributory factors namely housewife burnout, perceived stress, and loneliness. The present study was a novel contribution to the literature investigating the mediating roles of those three contributory factors between psychological distress and anxiety among housewives. Participants were 500 volunteer housewives between the ages of 20 and 70 from Turkey. In addition to Demographic Information Form, The Perceived Stress Scales (PSS-10), The General Health Questionnaire (GHQ-12), The UCLA Loneliness Scale-Version 3 (UCLA LS3), The Housewives Burnout Questionnaire (CUBAC), and The Beck Anxiety Inventory (BAI) were used. Results showed that there were four paths between psychological distress and anxiety in the model, explaining 31.19% of the total variance in anxiety in housewives. The relationship between psychological distress and anxiety was mediated by perceived distress, loneliness, and housewife burnout. Specifically, the higher psychological distress and higher anxiety relationship were associated with higher perceived distress, higher loneliness, and higher housewife burnout. The findings provide beneficial insight for clinicians to prioritize the abandonment of the cope with loneliness, perceived stress, and burnout while working with housewives having psychological distress and anxiety.Yayın Design of multiband matching ladders without mutual coupling using parametric representation of Brune functions(John Wiley and Sons Inc, 2020-10-01) Yıldız, Serkan; Aksen, Ahmet; Yarman, Bekir Sıddık BinboğaIn this study, a semianalytical method for the design of mutual coupling free multiband matching networks is introduced. A new parametric representation of Brune functions is used for the construction of multiband ladder network topologies without mutual induction. The method involves the use of Fujisawa's constraints for low pass ladders having finite transmission zeros, in a parametric representation of driving point impedance function resulting in mutual inductance free Brune sections. The developed parametric representation is incorporated with Real Frequency Techniques to design matching networks with a plurality of pass bands. Several illustrative design examples are presented to validate the method.Yayın Impact of climate change and land cover dynamics on nitrate transport to surface waters(Springer Science and Business Media Deutschland GmbH, 2024-03) Boyacıoğlu, Hülya; Günaçtı, Mert Can; Barbaros, Filiz; Gül, Ali; Gül, Gülay Onuşluel; Öztürk, Tuğba; Kurnaz, M. LeventThe study investigated the impact of climate and land cover change on water quality. The novel contribution of the study was to investigate the individual and combined impacts of climate and land cover change on water quality with high spatial and temporal resolution in a basin in Turkey. The global circulation model MPI-ESM-MR was dynamically downscaled to 10-km resolution under the RCP8.5 emission scenario. The Soil and Water Assessment Tool (SWAT) was used to model stream flow and nitrate loads. The land cover model outputs that were produced by the Land Change Modeler (LCM) were used for these simulation studies. Results revealed that decreasing precipitation intensity driven by climate change could significantly reduce nitrate transport to surface waters. In the 2075–2100 period, nitrate-nitrogen (NO3-N) loads transported to surface water decreased by more than 75%. Furthermore, the transition predominantly from forestry to pastoral farming systems increased loads by about 6%. The study results indicated that fine-resolution land use and climate data lead to better model performance. Environmental managers can also benefit greatly from the LCM-based forecast of land use changes and the SWAT model’s attribution of changes in water quality to land use changes. Graphical abstract: (Figure presented.).Yayın k-Means clustering by using the calculated Z-scores from QEEG data of children with dyslexia(Taylor & Francis, 2023) Eroğlu, Günet; Arman, FehimLearning the subtype of dyslexia may help shorten the rehabilitation process and focus more on the relevant special education or diet for children with dyslexia. For this purpose, the resting-state eyes-open 2-min QEEG measurement data were collected from 112 children with dyslexia (84 male, 28 female) between 7 and 11 years old for 96 sessions per subject on average. The z-scores are calculated for each band power and each channel, and outliers are eliminated afterward. Using the k-Means clustering method, three different clusters are identified. Cluster 1 (19% of the cases) has positive z-scores for theta, alpha, beta-1, beta-2, and gamma-band powers in all channels. Cluster 2 (76% of the cases) has negative z-scores for theta, alpha, beta-1, beta-2, and gamma-band powers in all channels. Cluster 3 (5% of the cases) has positive z-scores for theta, alpha, beta-1, beta-2, and gamma-band powers at AF3, F3, FC5, and T7 channels and mostly negative z-scores for other channels. In Cluster 3, there is temporal disruption which is a typical description of dyslexia. In Cluster 1, there is a general brain inflammation as both slow and fast waves are detected in the same channels. In Cluster 2, there is a brain maturation delay and a mild inflammation. After Auto Train Brain training, most of the cases resemble more of Cluster 2, which may mean that inflammation is reduced and brain maturation delay comes up to the surface which might be the result of inflammation. Moreover, Cluster 2 center values at the posterior parts of the brain shift toward the mean values at these channels after 60 sessions. It means, Auto Train Brain training improves the posterior parts of the brain for children with dyslexia, which were the most relevant regions to be strengthened for dyslexia.
