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Yayın The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations(Turkish Neuropsychiatric Society, 2025-06-19) Çebi, Merve; Ay, Ulaş; Kıçik, Ani; Erdoğdu, Emel; Tepgeç, Fatih; Uyguner, Zehra Oya; Tüfekçioğlu, Zeynep; Samancı, Bedia; Bilgiç, Başar; Emre, Murat; Demiralp, Tamer; Hanağası, Haşmet AyhanIntroduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.Yayın Analyzing language ability in first-episode psychosis and their unaffected siblings: a diffusion tensor imaging tract-based spatial statistics analysis study(Elsevier Ltd, 2024-11) Çabuk, Tuğçe; Şahin Çevik, Didenur; Çakmak, Işık Batuhan; Yılmaz Kafalı, Helin; Şenol, Bedirhan; Avcı, Hanife; Karlı Oğuz, Kader; Toulopoulou, TimotheaSchizophrenia (SZ) is a highly heritable mental disorder, and language dysfunctions play a crucial role in diagnosing it. Although language-related symptoms such as disorganized speech were predicted by the polygenic risk for SZ which emphasized the common genetic liability for the disease, few studies investigated possible white matter integrity abnormalities in the language-related tracts in those at familial high-risk for SZ. Also, their results are not consistent. In this current study, we examined possible aberrations in language-related white matter tracts in patients with first-episode psychosis (FEP, N = 20), their siblings (SIB, N = 20), and healthy controls (CON, N = 20) by applying whole-brain Tract-Based Spatial Statistics and region-of-interest analyses. We also assessed language ability by Thought and Language Index (TLI) using Thematic Apperception Test (TAT) pictures and verbal fluency to see whether the scores of these language tests would predict the differences in these tracts. We found significant alterations in language-related tracts such as inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF) among three groups and between SIB and CON. We also proved partly their relationship with the language test as indicated by the significant correlation detected between TLI Impoverished thought/language sub-scale and ILF. We could not find any difference between FEP and CON. These results showed that the abnormalities, especially in the ILF and UF, could be important pathophysiological vulnerability indexes of schizophrenia. Further studies are required to understand better the role of language as a possible endophenotype in schizophrenia with larger samples.Yayın Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: a living systematic review with meta-analysis(Elsevier B.V., 2025-12) Højlund, Mikkel; Yılmaz Kafalı, Helin; Kırmızı, Begüm; Fusar-Poli, Paolo; Correll, Christoph U.; Cortese, Samuele; Sabé, Michel; Fiedorowicz, Jess; Saraf, Gayatri; Zein, Josephine; Berk, Michael; Husain, Muhammad I.; Rosenblat, Joshua D.; Rubaiyat, Ruby; Corace, Kim; Wong, Stanley; Hatcher, Simon; Kaluzienski, Mark; Yatham, Lakshmi N.; Cipriani, Andrea; Gosling, Corentin J.; Carhart-Harris, Robin; Tanuseputro, Peter; Myran, Daniel T.; Fabiano, Nicholas; Moher, David; Mayo, Leah M.; Nicholls, Stuart G.; White, Tracy; Prisco, Michele De; Radua, Joaquim; Vieta, Eduard; Ladha, Karim S.; Katz, Jay; Veroniki, Areti A.; Solmi, MarcoSerotonergic psychedelics and 3,4-methylendioxtmethamphetamine (MDMA) are promising treatments for mental disorders with a continuously evolving evidence base. We searched Pubmed/Scopus/clinical trial registries up to 08july2025 for double-blind randomized controlled trials (RCTs) testing MDMA or serotonergic psychedelics in patients with mental disorders. Primary outcomes were change in disease-specific symptoms and all-cause discontinuation. Standardized mean differences (SMD) and relative risk (RR) were estimated using random-effects meta-analysis. Risk of bias (RoB) was assessed with Cochrane’s RoB-tool version 2 and certainty of evidence with GRADE. The review is maintained as living systematic review ( https://ebipsyche-database.org/ ). We included 30 RCTs (1480 participants; female=45.8 %; with psychological support=83.3 %; high RoB=83.3 %). In post-traumatic stress disorder (PTSD), MDMA reduced PTSD symptoms compared to any control ( k = 11; SMD=-0.85 [-1.09; -0.60]; I2=0 %; GRADE=low). In major depressive disorder (MDD), psilocybin/ayahuasca/LSD reduced depressive symptoms ( k = 8; SMD=-0.62 [-0.97; -0.28]; I2=55 %; GRADE=very low). In anxiety disorders, both MDMA and serotonergic psychedelics reduced anxiety symptoms (SMDMDMA=-1.18 [-2.04; -0.32]; I2=0 %; k = 2; GRADE=low and SMDserotonergic=-0.88 [-1.70; -0.06]; I2=54 %; k = 5; GRADE=very low). In alcohol use disorder, neither psilocybin nor LSD reduced abstinence rates ( k = 6; RR=1.42 [0.89; 2.26]; I2=7 %; GRADE=very low). In attention-deficit hyperactivity disorder (ADHD), LSD did not reduce ADHD symptoms ( k = 1; SMD=0.22 [-0.32; 0.76]; GRADE=very low). Moderate certainty in evidence was only found for MDMA on PTSD symptoms when compared to placebo. MDMA/serotonergic psychedelics were not associated with higher risk of all-cause discontinuation (RRMDMA=0.74 [0.32; 1.72]; RRserotonergic=0.81 [0.56; 1.15]). Overall, MDMA/serotonergic psychedelics are promising for the treatment of PTSD, MDD, and anxiety disorders with moderate to large effect sizes. Pragmatic trials, long-term, head-to-head trials exploring the role of psychological support, aiming to identify predictors of response, and accounting for expectancy and functional unblinding are needed. Studies addressing these limitations will likely be required for regulatory approval of psychedelic drugs.Yayın Ebeveyn tutumları ve çocuk davranış problemleri arasındaki ilişkide ebeveyn mükemmeliyetçiliğinin aracı rolü(Galenos Publishing House, 2025-11-11) İnce, Merve; Akçınar, Berna; Yılmaz, SimayAmaç: Bu çalışma, annelerin mükemmeliyetçiliğinin, annelerin ebeveynlik stilleri ile çocukların içselleştirme ve dışsallaştırma davranış problemleri arasındaki ilişkide aracılık rolünü incelemeyi amaçlamaktadır. Gereç ve Yöntem: Örneklem, 3-6 yaş arası çocukları olan 271 anneden oluşmaktadır. Katılımcılardan sosyodemografik bilgi formu, Ebeveyn Tutum Ölçeği, Hacettepe Ruhsal Uyum Ölçeği ve Çok Boyutlu Mükemmeliyetçilik Ölçeğini doldurmaları istenmiş ve veriler çevrimiçi olarak toplanmıştır. Bulgular: Çalışmanın ana hipotezini test etmek için yapılan analiz bulgularına göre demokratik ebeveynlik, içselleştirme (b=-0,117, p<0,05) ve dışsallaştırma (b=-0,076, p<0,05) davranış problemlerini negatif yönde yordamıştır. Bu ilişkilerde annenin kendine yönelik mükemmeliyetçiliği (KYM) ve sosyal olarak belirlenen mükemmeliyetçilik (SBM) aracılık etmemiştir. Otoriter ebeveynlik, içselleştirme (b=0,046, p<0,05) ve dışsallaştırma (b=0,049, p<0,05) davranış problemleriyle pozitif yönde ilişkilendirilmiş ve bu problemler üzerindeki etkilerinde KYM ve SBM aracılık rolü üstlenmemiştir. Buna karşın, aşırı korumacı ve izin verici tutumlar bu davranış problemlerini anlamlı bir şekilde yordamamıştır. Ayrıca, annelerin KYM’nin, aşırı korumacı ve izin verici ebeveynlik tutumları ile içselleştirme ve dışsallaştırma davranış problemleri arasındaki ilişkide aracılık etkisi olmadığı bulunmuş; ancak SBM’nin aşırı koruyucu ebeveyn tutumu ile içselleştirme [b=0,017, standart hata (SH)=0,009, güven aralığı (GA): (0,003, 0,038)] ve dışsallaştırma [b=0,012, SH=0,007, GA: (0,001, 0,029)] davranış problemlerinde ve izin verici ebeveyn tutumu ile içselleştirme davranış problemi [b=0,013, SH=0,008, GA: (0,000, 0,033)] arasında aracılık etkisinde bulunduğu görülmüştür. Sonuç: Bu çalışma, ebeveynlik tutumları ve özelliklerinin çocukların ruh sağlığı üzerindeki önemli rolünü vurgulamakta, ebeveynlerin etkili ve olumlu ebeveynlik yaklaşımlarını benimsemeleri için pratik müdahalelerin gerekliliğini belirtmektedir.
