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Yayın “Can we use a biomarker detection algorithm to measure the effectiveness of 14-channel neurofeedback in dyslexia?”(Routledge, 2025-10-01) Eroğlu, Günet; Harb, Raja AbouDyslexia, one of children’s most common neurological diversities, primarily manifests as a reduced reading ability. Genetic factors contribute to dyslexia, with contemporary theories attributing it to a delay in left hemispheric lateralization that reduces effective reading and writing skills. To assist dyslexic children, smartphone application, Auto Train Brain, has been developed to enhance reading comprehension and speed. Previously, the efficacy of the mobile application’s training program was assessed using psychometric tests; however, our study employed a biomarker detection software to evaluate the neurofeedback’s impact. Machine learning (ML) techniques have recently gained traction in differentiating between dyslexia and typically developing children (TDC). The dataset of this study consists of 100 sessions of 2-minute resting-state eyes-open 14-channel Quantitative Electroencephalography (QEEG) data from 100 children with dyslexia and 100 TDC. Therefore, the dyslexia biomarker detection software assessed the efficacy of the 14-channel neurofeedback administered via Auto Train Brain. Results showed significant improvement in electrophysiological normalization, increasing from 30% in the first 20 sessions to 61% by the end of the training. A two-proportion Z-test confirmed this improvement was statistically significant (Z = −3.96, p = 0.00007), particularly between the 1–20 and 1–60 session intervals (Z = −2.66, p = 0.0079).Yayın Theta and Beta1 frequency band values predict dyslexia classification(John Wiley and Sons Ltd, 2025-12-29) Eroğlu, Günet; Harb, Mhd Raja AbouDyslexia, impacting children's reading skills, prompts families to seek cost-effective neurofeedback therapy solutions. Utilising machine learning, we identified predictive factors for dyslexia classification. Employing advanced techniques, we gathered 14-channel Quantitative Electroencephalography (QEEG) data from 200 participants, achieving 99.6% dyslexic classification accuracy through cross-validation. During validation, 48% of dyslexic children's sessions were consistently classified as normal, with a 95% confidence interval of 47.31 to 48.68. Focusing on individuals consistently diagnosed with dyslexia during therapy, we found that dyslexic individuals exhibited higher theta values and lower beta1 values compared to typically developing children. This study pioneers machine learning in predicting dyslexia classification factors, offering valuable insights for families considering neurofeedback therapy investment.Yayın Secure and interpretable dyslexia detection using homomorphic encryption and SHAP-based explanations(Institute of Electrical and Electronics Engineers Inc., 2025-10-25) Harb, Mhd Raja Abou; Çeliktaş, Barış; Eroğlu, GünetProtecting sensitive healthcare data during machine learning inference is critical, particularly in cloud-based environments. This study addresses the privacy and interpretability challenges in dyslexia detection using Quantitative EEG (QEEG) data. We propose a privacy-preserving framework utilizing Homomorphic Encryption (HE) to securely perform inference with an Artificial Neural Network (ANN). Due to the incompatibility of non-linear activation functions with encrypted arithmetic, we employ a dedicated approximation strategy. To ensure model interpretability without compromising privacy, SHapley Additive exPlanations (SHAP) are computed homomorphically and decrypted client-side. Experimental evaluations demonstrate that the encrypted inference achieves an accuracy of 90.03% and an AUC of 0.8218, reflecting only minor performance degradation compared to plaintext inference. SHAP value comparisons (Spearman correlation = 0.59) validate the reliability of the encrypted explanations. These results confirm that integrating privacy-preserving and explainable AI approaches is feasible for secure, ethical, and compliant healthcare deployments.
