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Yayın Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning(Springer Science and Business Media Deutschland GmbH, 2022-12) Cengiz, Sevim; Arslan, Dilek Betül; Kıçik, Ani; Erdoğdu, Emel; Yıldırım, Muhammed; Hatay, Gökçe Hale; Tüfekçioğlu, Zeynep; Uluğ, Aziz Müfit; Bilgiç, Başar; Hanagasi, Haşmet; Demiralp, Tamer; Gürvit, Hakan; Öztürk Işıkk, EsinObjective: To investigate metabolic changes of mild cognitive impairment in Parkinson’s disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (1H-MRSI). Methods: Sixteen healthy controls (HC), 26 cognitively normal Parkinson’s disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional 1H-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results: PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion: 1H-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as ‘posterior cortical metabolic changes’ related with cognitive dysfunction.Yayın NFC Loyal for enhancing loyalty services through Near Field Communication(Springer US, 2013-02) Özdenizci Köse, Büşra; Ok, Kerem; Coşkun, VedatNear Field Communication (NFC) as an emerging technology is currently leveraged by large standardization efforts and tries to find a suitable ecosystem. NFC enabled mobile devices with integrated smart cards introduce compelling opportunities and new business models. Development of new standards such as secure element (SE), smart card, secure channel, as well as JavaCard enables creating new ecosystems using a concurrent multi application platform which takes advantage of GlobalPlatform standards. We proposed NFC Loyal, which maintains storage, retrieval, and sharing among payment and loyalty applications through our proposed structure, called as Secure Common Domain Management (SCDM) system. SCDM as a centralized database management system on the SE stores valuable information provided by payment applications and shares them with loyalty applications through a secure channel. The direct outcome of using NFC Loyal is the increase in repeat purchases of customers; as well as being a beneficial business plan realized among the payment firms, loyalty firms, and the card owner, resulting in a win-win business model. In this study, we describe NFC Loyal model with its technical infrastructure, and present the NFC Loyal model's life cycle management on SE.Yayın Immitance data modelling via linear interpolation techniques: a classical circuit theory approach(Wiley-Blackwell, 2004-11) Yarman, Bekir Sıddık Binboğa; Kılınç, Ali; Aksen, AhmetWith the advancement of the manufacturing technologies to produce new generation analog/digital communication systems, immitance data modelling has gained renewed importance in the literature. Specifically, models are utilized for behaviour characterization, simulation of physical devices or to design sub-systems with active and passive solid-state devices. Therefore, in this paper, new computer aided tools are presented to model one port immitance data by means of linear interpolation techniques. The basic philosophy of the new modelling tools is based on the numerical decomposition of the immitance data into its minimum and Foster parts. Computer algorithms are presented to model the minimum and the Foster parts of the given immitance data. Implementations of these algorithms are exhibited by means of examples. Depending on the application, modelling tools based on linear interpolation techniques may present 'computational and practical' advantages over the existing interpolation techniques, non-linear curve fittings or regression methods. It is expected that the new modelling tools will be utilized to provide initial circuit topologies to the commercially available analysis/simulation and design packages.Yayın Energy and data cooperative multiple access channel with intermittent data arrivals(IEEE, 2018-03) Gürakan, Berk; Kaya, Onur; Ulukuş, ŞennurWe consider an energy harvesting two user cooperative Gaussian multiple access channel, where both of the users harvest energy from nature. The users cooperate at the physical layer (data cooperation) by establishing common messages through overheard signals and then cooperatively sending them. We study two scenarios within this model. In the first scenario, the data packets arrive intermittently over time. We find the optimal offline transmit power and rate allocation policy that maximize the departure region. We first show that there exists an optimal policy, in which the single user rate constraints in each time slot are tight, yielding a one-to-one relation between the powers and rates. Then, we formulate the departure region maximization problem as a weighted sum departure maximization in terms of rates only. Next, we propose a sequential convex approximation method to approximate the problem at each step and show that it converges to the optimal solution. We solve the approximate problems using an inner-outer decomposition method. In the second scenario, the data packets are available at the beginning of the transmission, but the users now have the ability to cooperate at the battery level (energy cooperation), in addition to data cooperation. The energy cooperation is facilitated by wireless energy transfer and is bidirectional. For this scenario, we find the jointly optimal offline transmit power and rate allocation policy together with the energy transfer policy that maximize the departure region. We provide necessary conditions for energy transfer and prove some properties of the optimal transmit policy, thereby shedding some light on the interplay between energy and data cooperation.Yayın A survey on Near Field Communication (NFC) technology(Springer, 2013-08) Coşkun, Vedat; Özdenizci Köse, Büşra; Ok, KeremNear Field Communication (NFC) as a promising short range wireless communication technology facilitates mobile phone usage of billions of people throughout the world that offers diverse services ranging from payment and loyalty applications to access keys for offices and houses. Eventually NFC technology integrates all such services into one single mobile phone. NFC technology has emerged lately, and consequently not much academic source is available yet. On the contrary, due to its promising business case options, there will be an increasing amount of work to be studied in the very close future. This paper presents the concept of NFC technology in a holistic approach with different perspectives, including communication essentials with standards, ecosystem and business issues, applications, and security issues. Open research areas and further recommended studies in terms of academic and business point of view are also explored and discussed at the end of each major subject's subsection. This comprehensive survey will be a valuable guide for researchers and academicians as well as for business world interested in NFC technology.Yayın Design and implementation of a smart beehive and its monitoring system using microservices in the context of IoT and open data(Elsevier B.V., 2022-05) Aydın, Şahin; Aydın, Mehmet NafizIt is essential to keep honey bees healthy for providing a sustainable ecological balance. One way of keeping honey bees healthy is to be able to monitor and control the general conditions in a beehive and also outside of a beehive. Monitoring systems offer an effective way of accessing, visualizing, sharing, and managing data that is gathered from performed agricultural and livestock activities for domain stakeholders. Such systems have recently been implemented based on wireless sensor networks (WSN) and IoT to monitor the activities of honey bees in beehives as well. Scholars have shown considerable interests in proposing IoT- and WSN-based beehive monitoring systems, but much of the research up to now lacks in proposing appropriate architecture for open data driven beehive monitoring systems. Developing a robust monitoring system based on a contemporary software architecture such as microservices can be of great help to be able to control the activities of honey bees and more importantly to be able to keep them healthy in beehives. This research sets out to design and implementation of a sustainable WSN-based beehive monitoring platform using a microservice architecture. We pointed out that by adopting microservices one can deal with long-standing problems with heterogeneity, interoperability, scalability, agility, reliability, maintainability issues, and in turn achieve sustainable WSN-based beehive monitoring systems.Yayın FSRFT - Fast simplified real frequency technique via selective target data approach for broadband double matching(IEEE, 2017-02) Köprü, RamazanThis brief introduces a broadband double-matching (DM) solver called fast simplified real frequency technique (FSRFT). FSRFT is essentially a greatly accelerated variant of the well-known classical simplified real frequency technique (SRFT). The basic idea that turns the classical SRFT into a 'fast' SRFT relies on two main approaches: the selective target data approach (STDA) and the constraint optimization approach (COA). STDA constructs an optimization target data set formed of only critically selected target data whose element number is equal to or slightly greater than the order of the system unknowns n plus 1, {n}+1. In order to exhibit speed performance comparison between SRFT and FSRFT, an example design is considered. An exemplary DM problem, dealing with an {n}=6th order low-pass Chebyshev-type equalizer design to match the given generator and load impedances, has been solved by SRFT within 29 s using 90 target data in a typical computer - e.g., Intel 2.20-GHz i7 CPU with 8-GB RAM. On the other hand, the same problem has been solved by the newly proposed FSRFT within only 0.6 s using only n+1=7 critically selected target data in the same computer. FSRFT introduced herein works in any domain, i.e., lumped, distributed, and mixed.Yayın An immitance based tool for modelling passive one-port devices by means of darlington equivalents(Urban & Fischer Verlag, 2001) Yarman, Bekir Sıddık Binboğa; Aksen, Ahmet; Kılınç, AliAn immitance-based method is presented to model measured or computed data, obtained from a "passive one-port physical device" by means of its Darlington equivalent. In other words, the given data is modelled as a lossless two port terminated in a unit resistor. The basis of the new modelling tool rests on the numerical decomposition of the given immitance data into its Foster and minimum parts. Therefore, the proposed technique does not require any choice for the circuit topology to build the model. Rather, the optimum circuit topology that characterises the given data is the natural consequence of the modelling process proposed in this paper. A main algorithm is presented to construct the model from the given data. It is expected that the proposed modelling tool will find practical applications in the behaviour characterisation, simulation, and design of high speed/high frequency analog/digital mobile communication sub-systems manufactured on VLSI chips. An antenna-modelling example is included to systematically exhibit the implementation of the modelling technique.Yayın Force-directed approaches to sensor localization(Assoc Computing Machinery, 2010-09) Efrat, Alon; Forrester, David; Iyer, Anand; Kobourov, Stephen G.; Erten, Cesim; Kılıç, Yasin OzanAs the number of applications of sensor networks increases, so does the interest in sensor network localization, that is, in recovering the correct position of each node in a network of sensors from partial connectivity information such as adjacency, range, or angle between neighboring nodes. In this article, we consider the anchor-free localization problem in sensor networks that report possibly noisy range information and angular information about the relative order of each sensor's neighbors. Previously proposed techniques seem to successfully reconstruct the original positions of the nodes for relatively small networks with nodes distributed in simple regions. However, these techniques do not scale well with network size and yield poor results with nonconvex or nonsimple underlying topology. Moreover, the distributed nature of the problem makes some of the centralized techniques inapplicable in distributed settings. To address these problems we describe a multiscale dead-reckoning (MSDR) algorithm that scales well for large networks, can reconstruct complex underlying topologies, and is resilient to noise. The MSDR algorithm takes its roots from classic force-directed graph layout computation techniques. These techniques are augmented with a multiscale extension to handle the scalability issue and with a dead-reckoning extension to overcome the problems arising with nonsimple topologies. Furthermore, we show that the distributed version of the MSDR algorithm performs as well as, if not better than, its centralized counterpart, as shown by the quality of the layout, measured in terms of the accuracy of the computed pairwise distances between sensors in the network.Yayın The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations(Turkish Neuropsychiatric Society, 2025-06-19) Çebi, Merve; Ay, Ulaş; Kıçik, Ani; Erdoğdu, Emel; Tepgeç, Fatih; Uyguner, Zehra Oya; Tüfekçioğlu, Zeynep; Samancı, Bedia; Bilgiç, Başar; Emre, Murat; Demiralp, Tamer; Hanağası, Haşmet AyhanIntroduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.
