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Erişim Hakkı: info:eu-repo/semantics/openAccess × Konu: Bipolar disorder ×

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  • Küçük Resim
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    Paraoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorder
    (Psikofarmakoloji Derneği adına Mesut Çetin, 2017) Yıldız, Mesut; Çam Çelikel, Feryal; Ateş, Ömer; Erdoğan Taycan, Serap; Benli, İsmail; Demir, Osman
    Objective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depressive disorder and bipolar disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: There were no statistically significant differences between groups for the existence of PON1 genotypes. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.
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    Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries
    (Elsevier Ireland Ltd, 2025-06) Fountoulakis, Konstantinos N.; Karakatsoulis, Gregory; Abraham, Seri; Adorjan, Kristina; Uddin Ahmed, Helal; Alarcòn, Renato Daniel; Arai, Kiyomi; Auwal, Sani Salihu; Berk, Michael; Levaj, Sarah; Yılmaz Kafalı, Helin
    Introduction: This study registered rates of specific treatment options for mental disorders as well as their long-term outcome. Material and methods: The history of mental disorders was used as a proxy for diagnosis. The data came from the COMET-G study (40 countries; 54,826 subjects, 64.73 % females, 35.45±13.51 years old). The analysis included descriptive statistics, Risk Ratios, t-tests, and ANCOVA's. Results: 24.14 % reported a history of any mental disorder (depression >12 %, non-affective psychosis and Bipolar disorder 1 % each, >20 % self-injury, >10 % had attempted suicide, 7.17 % illegal substance abuse). Most patients were not under any kind of treatment (59.44 %) and most were not receiving treatment as recommended (e.g. 90 % of Bipolar and 2/3 of psychotic patients). No treatment at all and psychotherapy as monotherapy were consistently related to poorer outcomes. In anxiety or depression, only antidepressant monotherapy and benzodiazepines, in Bipolar disorder only antipsychotic monotherapy in males and antidepressant monotherapy in females and in non-affective psychosis antipsychotics and psychotherapy in females only, were related to good outcomes. No treatment modality was related to a good outcome in those with a history of self-harm, suicidal attempts, or illegal substance use. Only depression and treatment with antidepressants were related to metabolic syndrome. Discussion: In the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a difference.
  • Küçük Resim
    Yayın
    Bipolar bozuklukta çalışma statüsü ve ilaç uyumu: "kuram temelli bir değerlendirme"
    (İstanbul Bilgi Üniversitesi, 2021-10-04) Ünver, Buket; Berk, Özlem Sertel; Karamustafalıoğlu, Nesrin
    Bu çalışmanın amacı ilaç uyumunun farklı çalışma statüsüne sahip bipolar bozukluk tanılı hastalarda nasıl farklılaştığını sağlık davranış modellerinden biri olan Bütünleşik Davranış Modeli (BDM) perspektifinden incelemek ve çalışma statüsünün hastalık şiddeti ve sosyodemografik değişkenlerle olan ilişkisini değerlendirmektir. Bu amaç doğrultusunda 167 bipolar bozukluk tanılı hastaya ulaşılmıştır. Veri toplama araçları olarak BDM Bipolar Bozukluk İlaç Uyumu Bataryası, Tıbbi Tedaviye Uyum Oranı Ölçeği ve İlaç Uyumunu Bildirim Ölçeği, kanda ölçülen ilaç düzeyi açısından ilaç uyumu kullanılmıştır. Yapılan analizler sonucunda memurların diğer çalışma statüsüne sahip gruplara göre hem hastalık şiddetinin hem de ilaç uyumsuzluğunun daha yüksek olduğu saptanmıştır. Özellikle bipolar bozukluk tanılı memur gruplarında ilaç uyumuna yönelik müdahale programlarına ihtiyaç duyulduğu düşünülmektedir.