2 sonuçlar
Arama Sonuçları
Listeleniyor 1 - 2 / 2
Yayın Cognitive bias modification of attention is less effective under working memory load(Springer New York LLC, 2014-07-20) Booth, Robert William; Mackintosh, Bundy; Mobini, Sirous; Öztop, Pınar; Nunn, SamanthaCognitive bias modification for attentional bias (CBM-A) attempts to alleviate anxiety by training an attentional bias away from threat. Several authors have argued that CBM-A in fact trains top-down, reactive counteraction of the tendency to orient towards threat. Imposing a working memory (WM) load during training should therefore limit its efficacy, since WM resources are required for goal-driven control of attention. Twenty-eight subclinical high-anxious participants completed two sessions of CBM-A or placebo training: one under a high WM load, and one under a low WM load. Attentional bias was assessed after each training. CBM-A produced an attentional bias away from threat under low load, but not under high load. These results suggest CBM-A trains top-down counteraction of orienting to threat. It also suggests the administration of CBM-A in the home environment may be affected by everyday worries and distractions.Yayın Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy(Taylor & Francis, 2023-03-04) Orhun, Günseli; Esen, Figen; Yılmaz, Vuslat; Ulusoy, Canan; Şanlı, Elif; Yıldırım, Elif; Gürvit, İbrahim Hakan; Ergin Özcan, Perihan; Sencer, Serra; Bebek, Nerses; Tüzün, ErdemPurpose: Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis that may lead to cognitive decline. Our aim was to investigate whether the neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could be utilized as prognostic biomarkers in SAE. Materials and methods: In this prospective observational study, baseline serum levels of sTREM2 and cerebrospinal fluid (CSF) levels of sTREM2 and NFL were measured by ELISA in 11 SAE patients and controls. Patients underwent daily neurological examination. Brain magnetic resonance imaging (MRI) and standard electroencephalography (EEG) were performed. Cognitive dysfunction was longitudinally assessed after discharge in 4 SAE patients using the Mini-Mental State Examination (MMSE) and Addenbrooke’s Cognitive Examination-Revised (ACE-R) tests. Results: SAE patients showed higher CSF sTREM2 and NFL levels than controls. sTREM2 and NFL levels were not correlated with the severity measures of sepsis. Three months after discharge, 2 SAE patients displayed ACE-R scores congruent with mild cognitive impairment (MCI), persisting in one patient 12 months after discharge. SAE patients with MCI showed higher CSF NFL levels, bacteremia, and abnormal brain MRI. Patients with increased serum/CSF sTREM2 levels showed trends towards displaying poorer attention/orientation and visuo-spatial skills. Conclusions: sTREM2 and NFL levels may serve as a prognostic biomarker for cognitive decline in SAE. These results lend further support for the involvement of glial activation and neuroaxonal degeneration in the physiopathology of SAE.
