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  • Küçük Resim
    Yayın
    Left/right and front/back in sign, speech, and co-speech gestures: what do data from Turkish sign language, croatian sign language, American sign language, Turkish, Croatian, and English reveal?
    (Versita, 2011-09) Arık, Engin
    Research has shown that spoken languages differ from each other in their representation of space. Using hands, body, and physical space in front of signers to represent space, do sign languages differ from each other? To what extent are they similar to spoken languages in their expressions of spatial relations? The present study targeted these questions by exploring the descriptions of static situations in sign languages (Turkish Sign Language, Croatian Sign Language, American Sign Language) and spoken languages, including co-speech gestures (Turkish, Croatian, and English). It is found that signed and spoken languages differ from each other in their linguistic constructions for the left/right and front/back spatial relation. They also differ from one another in their mapping strategies. Crucially, being a signer does not require more direct iconic mappings than a speaker would use. It is also found that co-speech gestures can complement spoken language descriptions.
  • Küçük Resim
    Yayın
    Formal thought disorder and familial risk in first-episode psychosis: A study of cortical thickness and neuroimaging-transcriptomic association analysis
    (Elsevier Ireland Ltd, 2026-01-16) Çabuk, Tuğçe; Zhang, Yuanchao; Palaniyappan, Lena; Şahin Çevik, Didenur; Avcı, Hanife; Çakmak, Işık Batuhan; Yılmaz Kafalı, Helin; Şenol, Bedirhan; Karlı Oğuz, Kader; Toulopoulou, Timothea
    Formal thought disorder (FTD), a prominent feature of schizophrenia, encompasses disruptions in thought, language, and communication. This study examines cortical thickness (CT) alterations in first-episode psychosis (FEP) patients (N = 24), their siblings (SIB) (N = 21), and healthy controls (CON) (N = 21) to explore potential neural correlates of FTD. Using structural MRI, we analyzed whole-brain CT and its relationship with positive and negative FTD measured by Thought and Language Index. Out-of-sample spatial correlations of gene expression with regional CT were also performed using a transcriptomic dataset. FEP had significant CT reductions in right middle frontal gyrus (MFG) compared with SIB and CON and in superior frontal gyrus (SFG) compared to CON; but SIB did not differ from CON. GLM analyses demonstrated that negative FTD exerted a significant main effect on CT in the MFG and SFG. By contrast, positive FTD showed no significant associations with CT. Neuroimaging-transcriptomic association analysis identified key biological pathways linked to cortical morphology. These findings emphasize the specific association between negative FTD and CT alterations in frontal brain regions, confirming prior reports. Future research should examine larger cohorts and investigate additional FTD subtypes to further elucidate neural correlates and potential familial risks of schizophrenia.