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Yayın Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning(Springer Science and Business Media Deutschland GmbH, 2022-12) Cengiz, Sevim; Arslan, Dilek Betül; Kıçik, Ani; Erdoğdu, Emel; Yıldırım, Muhammed; Hatay, Gökçe Hale; Tüfekçioğlu, Zeynep; Uluğ, Aziz Müfit; Bilgiç, Başar; Hanagasi, Haşmet; Demiralp, Tamer; Gürvit, Hakan; Öztürk Işıkk, EsinObjective: To investigate metabolic changes of mild cognitive impairment in Parkinson’s disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (1H-MRSI). Methods: Sixteen healthy controls (HC), 26 cognitively normal Parkinson’s disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional 1H-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results: PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion: 1H-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as ‘posterior cortical metabolic changes’ related with cognitive dysfunction.Yayın NFC Loyal for enhancing loyalty services through Near Field Communication(Springer US, 2013-02) Özdenizci Köse, Büşra; Ok, Kerem; Coşkun, VedatNear Field Communication (NFC) as an emerging technology is currently leveraged by large standardization efforts and tries to find a suitable ecosystem. NFC enabled mobile devices with integrated smart cards introduce compelling opportunities and new business models. Development of new standards such as secure element (SE), smart card, secure channel, as well as JavaCard enables creating new ecosystems using a concurrent multi application platform which takes advantage of GlobalPlatform standards. We proposed NFC Loyal, which maintains storage, retrieval, and sharing among payment and loyalty applications through our proposed structure, called as Secure Common Domain Management (SCDM) system. SCDM as a centralized database management system on the SE stores valuable information provided by payment applications and shares them with loyalty applications through a secure channel. The direct outcome of using NFC Loyal is the increase in repeat purchases of customers; as well as being a beneficial business plan realized among the payment firms, loyalty firms, and the card owner, resulting in a win-win business model. In this study, we describe NFC Loyal model with its technical infrastructure, and present the NFC Loyal model's life cycle management on SE.Yayın Immitance data modelling via linear interpolation techniques: a classical circuit theory approach(Wiley-Blackwell, 2004-11) Yarman, Bekir Sıddık Binboğa; Kılınç, Ali; Aksen, AhmetWith the advancement of the manufacturing technologies to produce new generation analog/digital communication systems, immitance data modelling has gained renewed importance in the literature. Specifically, models are utilized for behaviour characterization, simulation of physical devices or to design sub-systems with active and passive solid-state devices. Therefore, in this paper, new computer aided tools are presented to model one port immitance data by means of linear interpolation techniques. The basic philosophy of the new modelling tools is based on the numerical decomposition of the immitance data into its minimum and Foster parts. Computer algorithms are presented to model the minimum and the Foster parts of the given immitance data. Implementations of these algorithms are exhibited by means of examples. Depending on the application, modelling tools based on linear interpolation techniques may present 'computational and practical' advantages over the existing interpolation techniques, non-linear curve fittings or regression methods. It is expected that the new modelling tools will be utilized to provide initial circuit topologies to the commercially available analysis/simulation and design packages.Yayın A survey on Near Field Communication (NFC) technology(Springer, 2013-08) Coşkun, Vedat; Özdenizci Köse, Büşra; Ok, KeremNear Field Communication (NFC) as a promising short range wireless communication technology facilitates mobile phone usage of billions of people throughout the world that offers diverse services ranging from payment and loyalty applications to access keys for offices and houses. Eventually NFC technology integrates all such services into one single mobile phone. NFC technology has emerged lately, and consequently not much academic source is available yet. On the contrary, due to its promising business case options, there will be an increasing amount of work to be studied in the very close future. This paper presents the concept of NFC technology in a holistic approach with different perspectives, including communication essentials with standards, ecosystem and business issues, applications, and security issues. Open research areas and further recommended studies in terms of academic and business point of view are also explored and discussed at the end of each major subject's subsection. This comprehensive survey will be a valuable guide for researchers and academicians as well as for business world interested in NFC technology.Yayın Investigation of symptom-specific functional connectivity patterns in Parkinson’s disease(Springer-Verlag Italia S.R.L., 2025-06-14) Kıçik, Ani; Bayram, Ali; Erdoğdu, Emel; Kurt, Elif; Sarıdede, Dilek Betül; Cengiz, Sevim; Bilgiç, Başar; Hanağası, Haşmet; Öztürk Işık, Esin; Gürvit, Hakan; Tüzün, Erdem; Demiralp, TamerParkinson’s disease (PD) is a complex neurodegenerative disease, characterized by pronounced heterogeneity in symptoms. This study investigates the functional connectivity (FC) patterns associated with distinct symptom clusters, aiming to elucidate the heterogeneity in PD and uncover the neural mechanisms underlying its motor and cognitive symptoms. Resting-state functional MRI (rs-fMRI) data from 55 non-demented PD patients and 24 healthy controls (HC) were used to perform seed-to-seed FC analyses. A clustering algorithm was applied to the cognitive and motor scores of all PD patients to generate relatively homogeneous symptomatic subgroups. PD patients exhibited a general decrease in FC within a network comprising the sensorimotor network (SMN) and the visual network (VN) regions. Symptom-based clustering revealed three relatively homogeneous subgroups, exhibiting a gradient pattern: patients with greater motor deficits showed significant disconnection within the SMN, whereas patients with greater visuospatial deficits exhibited reduced FC in an extended subnetwork, with pronounced disconnections between the VN and SMN areas. Our study demonstrated a notable disconnection between the SMN and VN, indicating impaired visual-motor integration in PD. Stronger disconnection within the SMN was associated with greater motor dysfunction, and stronger visual-sensorimotor disconnections were associated with greater visuospatial deficits. These findings suggest that at least two separate routes of functional disconnection may be responsible for the inhomogeneous symptom distribution in PD.
