Computational model of the ventricular action potential in adult spontaneously hypertensive rats
Künye
Padmala, S. & Demir, S. S. (2003). Computational model of the ventricular action potential in adult spontaneously hypertensive rats.Journal of Cardiovascular Electrophysiology. 14(9), 990-995. doi:10.1046/j.1540-8167.2003.03086.xÖzet
Introduction: Cardiac hypertrophy has substantial clinical significance because many hypertrophic cells have markedly prolonged repolarization behavior, which may lead to increased risk for cardiac arrhythmias. Spontaneously hypertensive rat (SHR) is one model of hypertension that is studied extensively and is considered to be the best laboratory model of human hypertension. We extended our previously published model of the rat ventricular myocyte to simulate the effects of hypertrophy in SHR. Methods and Results: In SHR it has been shown that the membrane capacitance is increased, the density of transient outward K+ current is decreased, the sarcoplasmic reticulum Ca 2+ ATPase activity is reduced, and the cell volumes are increased compared to those of the normal rat. We introduced these changes into our previous model of the rat ventricular myocyte and simulated the ventricular action potential of SHR. Our results demonstrated increased action potential duration (APD) and increased peak systolic value of the intracellular calcium transient in SHR. Simulations with reduced extracellular K+ concentration ([K+]o) have shown that there is increased APD shortening in SHR compared to that of the normal rat. Conclusions: Our computational model qualitatively simulated the electrophysiologic changes observed in SHR and provided the plausible mechanistic linkage between the prolonged APD and increased inotropy. Our model results also demonstrated the electrophysiologic changes observed with reduced [K+]o in SHR, a finding that is clinically significant in hypertensive patients with left ventricular hypertrophy undergoing diuretic treatment.
Kaynak
Journal of Cardiovascular ElectrophysiologyCilt
14Sayı
9İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
On the Origin and Age of the Ariburnu Beachrock, Gelibolu Peninsula, Turkey
Erginal, Ahmet Evren; Güneç Kıyak, Nafiye; Bozcu, Mustafa; Ertek, Topçu Ahmet; Güngüneş, Hakan; Sungur, Ali; Türker, Gülen (Scientific Technical Research Council Turkey-TUBITAK, 2008-03-13)The beachrock formation on the Ariburnu coast situated in the Gelibolu Peninsula has been studied by field observation, thin-section interpretation, physicochemical analyses including ICP-AES and SEM/EDS, and OSL dating. ... -
Monovalent and divalent cation effects on phase transitions of iota-carrageenan
Kara, Selim; Arda, Ertan; Pekcan, Mehmet Önder (Sage Publications Ltd, 2007-01)Phase transitions Of L-carrageenan in a variety of monovalent (Li, Na, K) and divalent (Mg, Ca, Sr) cation solutions were studied during heating and cooling by using photon transmission technique. Photon transmission ... -
Swelling of iota-carrageenan gels prepared with various CaCl2 content: A fluorescence study
Tarı İlgin, Özlem; Pekcan, Mehmet Önder (European Polymer Federation, 2008-01-05)Iota carrageenan gels prepared with various CaCl2 content were completely dried and then swelled in water vapor. Steady-state fluorescence ( SSF) technique was used to monitor the swelling process of each iota carrageenan ...