Detection of visual and frontoparietal network perfusion deficits in Parkinson's disease dementia
Yükleniyor...
Dosyalar
Tarih
2021-11
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Mild cognitive impairment of Parkinson's disease (PD) may be an early manifestation that may progressively worsen to dementia. Cognitive decline has been associated with changes in the brain perfusion pattern. This study aimed to evaluate cerebral blood flow (CBF) deficits specific to different stages of cognitive decline. Seventeen patients with cognitively normal PD (PD-CN), 18 patients with PD with mild cognitive impairment (PD-MCI), and 16 patients with PD with dementia (PDD) were included in this study. The participants were scanned using a 3 T Philips MRI scanner. Arterial spin labelling magnetic resonance (ASL-MR) images were acquired, followed by calculation of the CBF maps, and registration onto the MNI152 brain atlas. A whole-brain voxel-based CBF comparison was performed among the patient groups using age as a covariate. The mean age of patients with PDD was significantly higher than that of patients with PD-MCI (P = 0.015) and PD-CN (P = 0.001). The CBF values of the three groups were significantly different in the left cuneus of the visual network (VN), left inferior frontal gyrus of the frontoparietal network (FPN), and left dorsomedial nucleus of the thalamus. PDD had lower perfusion values than PD-MCI group in the same regions detected in the main group analysis. Additionally, comparison of PDD with PD-CN and non-demented groups revealed that the perfusion reduction extended into the bilateral cuneus of the VN, bilateral thalami, and left inferior frontal gyrus of the FPN. PDD could be separated from PD-MCI and PD-CN stages with CBF deficits in non-dopaminergically mediated posterior and dopaminergically mediated frontal networks.
Açıklama
Anahtar Kelimeler
Arterial Spin Labelling Magnetic Resonance, Architecture, Diagnostic-criteria, Hypoperfusion, Imaging (ASL-MRI), Mild cognitive impairment with Parkinson's disease (PD-MCI), Mild cognitive impairment, Organization, Parkinson Disease dementia (PDD), Parkinson Disease (PD), Pathology, Progression, Resting state functional MRI (rs-fMRI) networks
Kaynak
European Journal of Radiology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
144
Sayı
Künye
Azamat, S., Arslan, D. B., Erdoğdu, E., Kıçik, A., Cengiz, S., Eryürek, K., Tüfekçioğlu, Z., Bilgiç, B., Hanagasi, H., Demiralp, T., Gürvit, H. & Öztürk Işık, E. (2021). Detection of visual and frontoparietal network perfusion deficits in Parkinson's disease dementia. European Journal of Radiology, 144, 1-7. doi:10.1016/j.ejrad.2021.109985
