Formal thought disorder and familial risk in first-episode psychosis: A study of cortical thickness and neuroimaging-transcriptomic association analysis

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dc.authorid0000-0003-1640-7182
dc.authorid0000-0001-9377-3560
dc.authorid0000-0002-1405-9754
dc.authorid0000-0003-2779-3947
dc.authorid0000-0002-6009-1085
dc.authorid0000-0002-0611-1858
dc.authorid0000-0002-3385-4665
dc.contributor.authorÇabuk, Tuğçeen_US
dc.contributor.authorZhang, Yuanchaoen_US
dc.contributor.authorPalaniyappan, Lenaen_US
dc.contributor.authorŞahin Çevik, Didenuren_US
dc.contributor.authorAvcı, Hanifeen_US
dc.contributor.authorÇakmak, Işık Batuhanen_US
dc.contributor.authorYılmaz Kafalı, Helinen_US
dc.contributor.authorŞenol, Bedirhanen_US
dc.contributor.authorKarlı Oğuz, Kaderen_US
dc.contributor.authorToulopoulou, Timotheaen_US
dc.date.accessioned2026-02-06T08:29:29Z
dc.date.available2026-02-06T08:29:29Z
dc.date.issued2026-01-16
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.description.abstractFormal thought disorder (FTD), a prominent feature of schizophrenia, encompasses disruptions in thought, language, and communication. This study examines cortical thickness (CT) alterations in first-episode psychosis (FEP) patients (N = 24), their siblings (SIB) (N = 21), and healthy controls (CON) (N = 21) to explore potential neural correlates of FTD. Using structural MRI, we analyzed whole-brain CT and its relationship with positive and negative FTD measured by Thought and Language Index. Out-of-sample spatial correlations of gene expression with regional CT were also performed using a transcriptomic dataset. FEP had significant CT reductions in right middle frontal gyrus (MFG) compared with SIB and CON and in superior frontal gyrus (SFG) compared to CON; but SIB did not differ from CON. GLM analyses demonstrated that negative FTD exerted a significant main effect on CT in the MFG and SFG. By contrast, positive FTD showed no significant associations with CT. Neuroimaging-transcriptomic association analysis identified key biological pathways linked to cortical morphology. These findings emphasize the specific association between negative FTD and CT alterations in frontal brain regions, confirming prior reports. Future research should examine larger cohorts and investigate additional FTD subtypes to further elucidate neural correlates and potential familial risks of schizophrenia.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationÇabuk, T., Zhang, Y., Palaniyappan, L., Şahin Çevik, D., Avcı, H., Çakmak, I. B., Yılmaz Kafalı, H., Şenol, B., Karlı Oğuz, K. & Toulopoulou, T. (2026). Formal thought disorder and familial risk in first-episode psychosis: A study of cortical thickness and neuroimaging-transcriptomic association analysis. Psychiatry Research - Neuroimaging, 357, 1-8. doi:https://doi.org/10.1016/j.pscychresns.2026.112148en_US
dc.identifier.doi10.1016/j.pscychresns.2026.112148
dc.identifier.endpage8
dc.identifier.issn0925-4927
dc.identifier.pmid41579632
dc.identifier.scopus2-s2.0-105028020156
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/6982
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2026.112148
dc.identifier.volume357
dc.identifier.wosWOS:001677986900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorYılmaz Kafalı, Helinen_US
dc.institutionauthorid0000-0002-6009-1085
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research - Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCortical thicknessen_US
dc.subjectFirst-episode psychosisen_US
dc.subjectFormal thought disorderen_US
dc.subjectLanguage disorderen_US
dc.subjectMrien_US
dc.subjectNeuroimaging-transcriptomic association analysisen_US
dc.subjectSiblingen_US
dc.subjectAnalysisen_US
dc.subjectSchizophreniaen_US
dc.subjectLanguageen_US
dc.subjectReductionsen_US
dc.titleFormal thought disorder and familial risk in first-episode psychosis: A study of cortical thickness and neuroimaging-transcriptomic association analysisen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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