Effect of modulated anodal stimulation over the dorsolateral prefrontal cortex on working memory: a preliminary study

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dc.authorid0000-0003-4729-8556
dc.authorid0000-0002-6209-6912
dc.authorid0000-0001-6612-5234
dc.authorid0000-0002-7534-9392
dc.contributor.authorKüçük, Zeynepen_US
dc.contributor.authorErdoğan, Ezgi Tunaen_US
dc.contributor.authorKurt, Adnanen_US
dc.contributor.authorKaramürsel, Saciten_US
dc.date.accessioned2026-01-21T08:38:33Z
dc.date.available2026-01-21T08:38:33Z
dc.date.issued2025-12-31
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.description.abstractObjectives: Working memory has two components: temporary storage and manipulation of the information necessary for cognitive behavior through the central executive system. This study aimed to investigate the effects of modulated anodal transcranial direct current stimulation (mtDCS) of the dorsolateral prefrontal cortex on working memory. Materials and Methods: Twelve volunteers without neurological or psychiatric disorders and without drug use participated. Working memory performance was assessed with a visual 3-back task using consonant letters during stimulation. A 20/minute training session was conducted to facilitate learning, and participants who achieved an accuracy rate of 50% or higher proceeded to the main experiment. Four stimulation conditions were applied, each lasting 10 minutes: mtDCS-11 Hz and mtDCS-22 Hz (1.70 mA offset, 0.35 mA peak/to/peak), direct current (DC) (2 mA), and sham. Reaction times and total correct responses were recorded. Results: Statistical analysis of the left dorsolateral prefrontal cortex (DLPFC) stimulation revealed a significant difference in the mean numbers of correct responses among the mtDCS and transcranial direct current stimulation (tDCS) conditions, but not compared with sham. The mean number of correct responses under mtDCS-11Hz and mtDCS-22Hz was significantly lower than under DC stimulation; however the performance decrement under 11 Hz mtDCS was the most pronounced among the active conditions. Conclusion: mtDCS-11Hz and mtDCS-22Hz negated the subtle facilitation of tDCS might have provided.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationKüçük, Z., Erdoğan, E. T., Kurt, A. & Karamürsel, S. (2025). Effect of modulated anodal stimulation over the dorsolateral prefrontal cortex on working memory: a preliminary study. Experimed, 15(3), 269-275. doi:https://doi.org/10.26650/experimed.1784343en_US
dc.identifier.doi10.26650/experimed.1784343
dc.identifier.endpage275
dc.identifier.issn2667-5846
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105025943958
dc.identifier.scopusqualityQ4
dc.identifier.startpage269
dc.identifier.urihttps://hdl.handle.net/11729/6942
dc.identifier.urihttps://doi.org/10.26650/experimed.1784343
dc.identifier.volume15
dc.identifier.wosWOS:001641844200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakEmerging Sources Citation Index (ESCI)en_US
dc.institutionauthorKüçük, Zeynepen_US
dc.institutionauthorid0000-0003-4729-8556
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherIstanbul Universityen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWorking memoryen_US
dc.subjectTranscranial direct current stimulationen_US
dc.subjectElectric stimulation therapyen_US
dc.titleEffect of modulated anodal stimulation over the dorsolateral prefrontal cortex on working memory: a preliminary studyen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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