The cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRI

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dc.authorid0000-0002-1124-3695
dc.authorid0000-0003-2908-8475
dc.authorid0000-0001-9734-8684
dc.authorid0000-0001-6625-6787
dc.authorid0000-0003-0482-3963
dc.authorid0000-0002-1332-3007
dc.authorid0000-0002-2817-5596
dc.authorid0000-0002-5128-1784
dc.authorid0000-0001-6989-8611
dc.authorid0000-0002-2315-0322
dc.authorid0000-0001-6032-0856
dc.authorid0000-0002-4624-4428
dc.authorid0000-0002-4483-0394
dc.authorid0000-0002-6803-734X
dc.authorid0000-0002-8997-878X
dc.contributor.authorArslan, Dilek Betülen_US
dc.contributor.authorGürvit, İbrahim Hakanen_US
dc.contributor.authorGenç, Ozanen_US
dc.contributor.authorKıçik, Anien_US
dc.contributor.authorEryürek, Kardelenen_US
dc.contributor.authorCengiz, Sevimen_US
dc.contributor.authorErdoğdu, Emelen_US
dc.contributor.authorYıldırım, Zerrinen_US
dc.contributor.authorTüfekçioğlu, Zeynepen_US
dc.contributor.authorUluğ, Aziz Müfiten_US
dc.contributor.authorBilgiç, Başaren_US
dc.contributor.authorHanağası, Haşmet Ayhanen_US
dc.contributor.authorTüzün, Erdemen_US
dc.contributor.authorDemiralp, Tameren_US
dc.contributor.authorÖztürk Işık, Esinen_US
dc.date.accessioned2020-07-24T07:04:16Z
dc.date.available2020-07-24T07:04:16Z
dc.date.issued2020-09
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.description.abstractParkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationArslan, D. B., Gürvit, İ. H., Genç, O., Kıçik, A., Eryürek, K., Cengiz, S., Erdoğdu, E., Yıldırım, Z., Tüfekçioğlu, Z., Uluğ, A. M., Bilgiç, B., Hanağası, H., Tüzün, E., Demiralp, T. & Öztürk Işık, E. (2020). The cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRI. Journal of Neural Transmission, 127(9),1285-1294. doi:10.1007/s00702-020-02227-6en_US
dc.identifier.doi10.1007/s00702-020-02227-6
dc.identifier.endpage1294
dc.identifier.issn0300-9564
dc.identifier.issn1435-1463
dc.identifier.issue9
dc.identifier.pmid32632889
dc.identifier.scopus2-s2.0-85087634329
dc.identifier.scopusqualityQ2
dc.identifier.startpage1285
dc.identifier.urihttps://hdl.handle.net/11729/2358
dc.identifier.urihttp://dx.doi.org/10.1007/s00702-020-02227-6
dc.identifier.volume127
dc.identifier.wosWOS:000545915200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.indekslendigikaynakSocial Sciences Citation Index (SSCI)en_US
dc.institutionauthorErdoğdu, Emelen_US
dc.institutionauthorid0000-0002-2817-5596
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Neural Transmissionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial spin labeling MRIen_US
dc.subjectCerebral blood flowen_US
dc.subjectParkinson's diseaseen_US
dc.subjectMild cognitive impairmenten_US
dc.subjectMicrotubule-associated protein tau (MAPT)en_US
dc.subjectFunctional connectivityen_US
dc.subjectCortical hypoperfusionen_US
dc.subjectDiagnostic-criteriaen_US
dc.subjectPerfusionen_US
dc.subjectDementiaen_US
dc.subjectOrganizationen_US
dc.subjectNetworken_US
dc.subjectProgressionen_US
dc.subjectPatternen_US
dc.subjectStateen_US
dc.titleThe cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRIen_US
dc.typeArticleen_US
dspace.entity.typePublication

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