The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response

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dc.authorid0000-0002-6009-1085
dc.authorid0000-0003-4372-1134
dc.authorid0000-0003-2442-9883
dc.authorid0000-0002-3795-5009
dc.authorid0000-0001-5691-2461
dc.contributor.authorYılmaz Kafalı, Helinen_US
dc.contributor.authorDaşgın, Haceren_US
dc.contributor.authorŞahin Çevik, Didenuren_US
dc.contributor.authorSozan, Sara Sinemen_US
dc.contributor.authorOğuz, Kader K.en_US
dc.contributor.authorMutlu, Mügeen_US
dc.contributor.authorÖzkaya Parlakay, Aslınuren_US
dc.contributor.authorToulopoulou, Timotheaen_US
dc.date.accessioned2023-12-07T13:11:26Z
dc.date.available2023-12-07T13:11:26Z
dc.date.issued2023-12en_US
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.descriptionThis work was supported by The Scientific and Technological Research Council of Turkey (TÜBİTAK) (Grant Number: 120K729 ) to TT.en_US
dc.description.abstractWe first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumuen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationYılmaz Kafalı, H., Daşgın, H., Şahin Çevik, D., Sozan, S. S., Oğuz, K. K., Mutlu, M., Özkaya Parlakay, A. & Toulopoulou, T. (2023). The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response. Psychiatry Research - Neuroimaging, 336, 1-8. doi:10.1016/j.pscychresns.2023.111746en_US
dc.identifier.doi10.1016/j.pscychresns.2023.111746
dc.identifier.endpage8
dc.identifier.issn0925-4927
dc.identifier.pmid37979347
dc.identifier.scopus2-s2.0-85177976635
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/5805
dc.identifier.urihttp://dx.doi.org/10.1016/j.pscychresns.2023.111746
dc.identifier.volume336
dc.identifier.wosWOS:001150025800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorYılmaz Kafalı, Helinen_US
dc.institutionauthorid0000-0002-6009-1085
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research - Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescenten_US
dc.subjectBrain networksen_US
dc.subjectCOVID-19en_US
dc.subjectFunctional connectivityen_US
dc.subjectInflammation markersen_US
dc.subjectNeuroimagingen_US
dc.subjectPsychosis pronenessen_US
dc.titleThe effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation responseen_US
dc.typeArticleen_US

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