Electrophysiological signatures of developmental dyslexia: towards EEG-based biomarker identification and neurogenetic correlates

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dc.authorid0009-0007-8239-8604
dc.authorid0009-0001-4214-8738
dc.contributor.authorEroğlu, Güneten_US
dc.contributor.authorHarb, Mhd Raja Abouen_US
dc.date.accessioned2025-10-08T07:30:56Z
dc.date.available2025-10-08T07:30:56Z
dc.date.issued2025-06-30
dc.departmentIşık Üniversitesi, Lisansüstü Eğitim Enstitüsü, Bilgisayar Mühendisliği Yüksek Lisans Programıen_US
dc.departmentIşık University, School of Graduate Studies, Master’s Program in Computer Engineeringen_US
dc.description.abstractDyslexia is a neurodevelopmental disorder characterized by altered hemispheric specialization and disrupted phonological processing. In this study, we applied Principal Component Analysis (PCA) to high-dimensional electroencephalographic (EEG) recordings from 200 children (100 dyslexic, 100 controls) to extract latent neurophysiological features associated with reading impairment. Our findings revealed significant right-hemisphere dominance in dyslexic individuals, particularly in the P8 electrode within the alpha band, consistent with compensatory neural strategies. Despite the absence of clinical comorbidities or medication use, distinct clustering emerged, supporting the utility of PCA for early screening. Future directions include correlating EEG-derived features with known dyslexia-related gene expression profiles (e.g., DCDC2, KIAA0319), neurotransmitter imbalances, and neuroinflammatory markers. These integrative analyses may establish EEG signals as reliable, non-invasive biomarkers for molecular-level screening in developmental learning disorders.en_US
dc.description.versionPreprint's Versionen_US
dc.identifier.citationEroğlu, G. & Harb, M. R. A. (2025). Electrophysiological signatures of developmental dyslexia: towards EEG-based biomarker identification and neurogenetic correlates. Preprints, 1-11. doi:https://doi.org/10.20944/preprints202506.2457.v1en_US
dc.identifier.endpage11
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/6754
dc.identifier.urihttps://doi.org/10.20944/preprints202506.2457.v1
dc.identifier.wosPPRN:156315381
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPreprint Citation Indexen_US
dc.institutionauthorHarb, Mhd Raja Abouen_US
dc.institutionauthorid0009-0001-4214-8738
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPreprintsen_US
dc.relation.publicationcategoryÖn Baskı – Uluslararası – Öğrencien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrincipal component analysisen_US
dc.subjectElectroencephalogramen_US
dc.subjectDyslexiaen_US
dc.titleElectrophysiological signatures of developmental dyslexia: towards EEG-based biomarker identification and neurogenetic correlatesen_US
dc.typePreprinten_US
dspace.entity.typePublicationen_US

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